This comics shop located in the windy streets of Harvard Square can be tough to locate, but it’s worth the effort. Million Year Picnic has been around for over 30 years, and has the unusual boast of catering to a large female readership. Great indie selection and great staff.
Easily the largest purveyor of comics in Boston, New England Comics caters more to mainstream crowds, though they carry a decent selection of indie comics. They’re also a publishing company, best known for The Tick comics.
Their motto of “Highbrow, lowbrow… and everything in between” sums up Comicopia pretty well. They seem to specialize in trade paperbacks, which are smartly shelved with an almost library feel.